Cardinals-Bills Week 1 betting odds and lines

It is officially Week 1 in the NFL season and the Arizona Cardinals prepare for their season opener on the road this week against the Buffalo Bills.

Their game kicks off on Sunday at 1 p.m. ET (10 a.m. Arizona time) from Highmark Stadium in Orchard Park, NY, with the game airing on CBS.

The Cardinals are coming off two straight four-win seasons and hope to take the step up into competing for the postseason, but face a Bills team that has Super Bowl aspirations after their fourth straight AFC East division title.

Let’s have a look at the betting odds and lines for the Cardinals vs. Bills Week 1 matchup. Odds are from BetMGM Sportsbook.

Cardinals at Bills betting odds and lines

Moneyline

• Cardinals +200 (Bet $100 to win $200)
• Bills -250 (Bet $250 to win $100)

With +200 odds, the Cardinals are given 33.33% implied odds of winning. The Bills’ implied odds of winning at -250 are 71.43%, so they are roughly 38% more likely to win than Arizona.

The Cardinals went 4-13 last season and the Bills were 12-7 including the postseason.

Against the spread (ATS)

• Cardinals +6 (-110)
• Bills -6 (-110)

If the Cardinals win, tie or lose by fewer than six points, a $110 ATS bet on the Cardinals would win $100.

If the Bills win by at least seven points, a $110 ATS bet wins $100.

The Cardinals were 9-8 ATS last season and the Bills were 8-11 ATS.

Total (Over/Under)

• Over 48.5 (-110)
• Under 48.5 (-110)

If the Cardinals and Bills combine for 49 or more points, a $110 bet on the Over would win $100.

The same bet on the Under would win the same amount if they combine for 48 or fewer points.

The Cardinals were 10-7 O/U last season while the Bills were 8-11 O/U.

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